ADAMTS-13 gene expression in antiphospholipid syndrome Antifosfolipid sendromunda ADAMTS-13 gen ekspresyonu
نویسندگان
چکیده
Veysel Sabri Hançer1, Reyhan Diz Küçükkaya2, Ayşegül Topal-Sarıkaya3 1Department of Medical Biology and Genetics, Faculty of Medicine, İstanbul Bilim University, İstanbul, Turkey 2Department of Internal Medicine, Division of Hematology, Faculty of Medicine, İstanbul Bilim University, İstanbul, Turkey 3Department of Molecular Biology and Genetics, Faculty of Science, İstanbul University, İstanbul, Turkey
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Human umbilical vein endothelial cell (HUVEC)–released ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin repeats) and HUVEC-secreted von Willebrand factor (VWF) strings were investigated under static conditions that allow the accumulation and analysis of ADAMTS-13. The latter was released constitutively from HUVECs and cleaved the secreted and cell-anchored VWF strings progressiv...
متن کاملFrequency of Pro475Ser Polymorphism of ADAMTS13 Gene and Its Association with ADAMTS-13 Activity in the Korean Population
PURPOSE The in vitro study suggested that proline to serine polymorphism in codon 475 (C1423T) of the A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats-13 (ADAMTS-13) gene is related to reduced activity of ADAMTS-13. In this study, the frequency of the Pro475Ser polymorphism in Koreans was studied and plasma ADAMTS-13 activity was measured to find out whether this polymorphis...
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